Management of fertility preservation in young female patients with gastrointestinal cancer: A case series and systematic literature review

Gastrointestinal (GI) cancers in young women pose significant challenges to fertility due to the gonadotoxic effects of chemotherapy, radiotherapy, and surgical interventions. While fertility preservation options exist, counseling remains underutilized, limiting patients' reproductive choices. This systematic review and case series examine the impact of GI cancer treatments on female fertility, available preservation techniques, pregnancy outcomes and sexual dysfunction. Despite advancements in fertility preservation, implementation remains suboptimal, underscoring the need for a multidisciplinary approach to improve counseling and reproductive outcomes. Raising awareness and promoting early intervention can enhance fertility preservation efforts and improve the quality of life for young female cancer survivors.